Cisplatin research

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August undefined, 2024

WebThe prevalence of cancer, in the world is increasing steadily. Despite intense research efforts, no approved therapy is yet available. Cisplatin is a chemotherapeutic drug but induces acute tissue injury. Oleuropein (OLE) is a major phenolic compound and used as a possible natural antioxidant, antimicrobial, and anticancer agent. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

Gene scissors find target for testicular cancer therapy

WebOct 11, 2024 · Defining the mechanisms by which cisplatin enters hair cells remains challenging, as cisplatin can enter cultured cells (see Figure 3A) across the cell membrane via passive diffusion ( Hall et al., 2008 ). In zebrafish neuromasts, hair cells with functional TMC1 channels (see Figure 3B) are more susceptible to cisplatin-induced cytotoxicity ... WebJul 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decreased intracellular concentration due to decreased drug uptake, increased reflux or increased inactivation by sulfhydryl molecules such as glutathione can cause resistance to cisplatin. Increased excision of the adducts from … software piracy cases 2020

Mechanisms of Aminoglycoside- and Cisplatin-Induced …

WebJan 14, 2024 · Chemotherapy Always Benefits the Cancer Center. Cancer centers significantly mark up chemotherapy drugs, which I cover in the article The Absurd … WebApr 1, 2016 · Cisplatin is currently one of the most effective chemotherapeutic drugs used for treating ovarian cancer; however, resistance to cisplatin is common. In this study, we explored an experimental strategy for overcoming cisplatin resistance of human ovarian cancer from the new perspective of cancer cell metabolism. WebCisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of cancer types. Unfortunately, many cancers initially respond to platinum treatment but … slow looper main: doframe

Cisplatin Sensitizes Cancer Cells to Ionizing Radiation via …

Enhanced Cisplatin Cytotoxicity by Disturbing the Nucleotide …

WebResearch Day 2024. Serum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen … WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to … software piracy case studyWebApr 13, 2024 · The chances of cure with this type of chemotherapy are exceptionally high for testicular cancer. However, in some patients the tumor develops cisplatin resistance, which is associated with a reduced survival rate. To get to the bottom of the causes of cisplatin resistance in testicular cancer, the Bonn research team used CRISPR gene scissors. software piracy business definition

"WebMost sources say that cisplatin is soluble in water and saline at around 1 mg/ml - 2.5 mg/ml depending on the source. I saw in the attached article (under liposome preparation method) that they ... " - Cisplatin research

Cisplatin research

Cisplatin - NCI - National Cancer Institute

Web2 days ago · Overactive gene NAE1 lifts the cell division brake. To get to the bottom of the causes of cisplatin resistance in testicular cancer, the Bonn research team used … WebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar …

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WebSep 24, 2024 · Cisplatin is a highly effective chemotherapeutic agent used to treat various cancers. Patients are administered controlled doses of cisplatin intravenously as an infusion. Even though cisplatin is very effective at its job, it has its own toxic side effects. WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion of cisplatin 50 mg/m2, administered during the …

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebChemical Name. cis-Diaminodichloroplatinum. Biological Activity. Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent …

WebCisplatin is in a class of medications known as platinum-containing compounds. It works by stopping or slowing the growth of cancer cells. How should this medicine be used? Cisplatin injection comes as a solution (liquid) to be injected over 6 to 8 hours intravenously (into a vein) by a doctor or nurse in a medical facility. WebFantastic. These were the words that kept coming up during the 40th Anniversary Cisplatin Celebration and Cancer Research Symposium, held Aug. 3-4 on the Michigan State University campus. The event marked the 40th anniversary of the FDA’s 1978 approval of the anti-cancer drug cisplatin. It was in the mid-1960s that MSU biophysicist Barnett ...

WebCisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas.

WebSep 20, 2024 · The most common adverse reactions in the two trials (≥25% with difference between arms of >5% compared to cisplatin alone) were vomiting, nausea, decreased hemoglobin, hypernatremia, and... slow loop pttWebMost sources say that cisplatin is soluble in water and saline at around 1 mg/ml - 2.5 mg/ml depending on the source. I saw in the attached article (under liposome preparation method) that they... software ping multiple ip addressesWebCisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis. Technical Data M.Wt: 300.05 Formula: software piracy finesWebCisplatin Injection is a sterile, multidose vial without preservatives. Store at 15° to 25°C (59° to 77°F). Do not refrigerate. Protect unopened container from light. The cisplatin remaining in... software pipeliningWebJan 18, 2024 · CX is the name of a combination of chemotherapy drugs; cisplatin and capecitabine. It is a treatment for a number of different types of cancer. ... Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666), the Isle of Man (1103) and Jersey (247). A company limited by guarantee. … slow loop fandomWebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … software piracy and related lawsWebCisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with other cancer … slow loop funimation