Iron-sulfur cluster assembly enzyme

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August undefined, 2024

WebJun 15, 2008 · The presence of an enzyme-bound persulfide at the end of the reaction was unambiguously demonstrated in the case of NifS from A. vinelandii [69] and later from the … WebNov 29, 2024 · Iron-sulfur (Fe-S) clusters are iron-containing prosthetic groups and enzymatic cofactors. They are strong oxidants when unbound yet essential in many processes like facilitating ATP production in mitochondria, promoting DNA, RNA and protein syntheses during cell proliferation and enhancing DNA repair in antioxidant defense.

Acute loss of iron-sulfur clusters results in metabolic ... - PubMed

WebMember of a biochemistry focused lab, under Dr. Timothy Stemmler, with a focus on the Iron-Sulfur Cluster Assembly Pathway. My thesis was the … WebMar 11, 2016 · 29.1 Iron-Sulfur Clusters (ISCU) Iron-sulphur cluster assembly enzyme, ISCU, is a protein coding gene which is engaged in repression of mitochondrial metabolism (Huang et al. 2010 ). In human, the two isoforms of ISCU exist as iron-sulphur (Fe-S) cluster scaffold protein, ISCU1 and ISCU2. ISCU1 is located in cytosol while ISCU2 presents in ... nutritional values of beets

Iron-Sulfur Cluster - an overview ScienceDirect Topics

WebOct 3, 2024 · Iron–sulfur (Fe–S) clusters are protein cofactors of a multitude of enzymes performing essential biological functions. Specialized multi-protein machineries present in all types of organisms support their biosynthesis. These machineries encompass a scaffold protein on which Fe–S clusters are assembled and a cysteine … WebMar 16, 2010 · The iron-sulfur cluster enzymes involved in valine, isoleucine, and leucine synthesis, IlvD and LeuC, ... Thus, if iron-sulfur cluster assembly is not shielded from … nutritional values of blueberries

ISCU iron-sulfur cluster assembly enzyme - NIH Genetic …

ISCU - Wikipedia

WebAssembly of iron-sulfur (Fe-S) clusters and maturation of Fe-S proteins in vivo require complex machineries. In Escherichia coli, under adverse stress conditions, this process is achieved by the SUF system that contains six proteins as … WebApr 13, 2024 · The intriguing role of iron-sulfur clusters in the ciapin1 protein family. ... The authors described that this complex is the molecular architecture built to provide electrons to the cluster bound to the CX8 CX2 CXC motif which can thus work as an electron reservoir for assembling cytosolic clusters and the diferric-tyrosyl radical cofactor of RNR. nutritional values of brown riceWebCurrently researching characterization of biophysical and structural properties of iron-sulfur cluster assembly proteins. Aspires to secure a professorship teaching in chemistry, biochemistry, and ... nutritional values of broccoli

"WebIron–sulfur proteins are proteins characterized by the presence of iron–sulfur clusters containing sulfide-linked di-, tri-, and tetrairon centers in variable oxidation states. … " - Iron-sulfur cluster assembly enzyme

Iron-sulfur cluster assembly enzyme

Iron–Sulfur Cluster States of the Hydrogenase Maturase HydF

WebApr 10, 2024 · The prokaryotic DNA repair enzyme PhrB, a member of the protein family of cryptochromes and photolyases, carries a four-iron-four-sulfur cluster ([4Fe4S]) in addition to the catalytic flavin and a second ribolumazine cofactors. The light-induced redox reactions of this multi-cofactor protein complex were recently shown as two … WebJul 22, 2024 · Of the three H-cluster maturases, HydG has been the most studied and best understood enzyme. It is a member of the radical S -adenosylmethionine (rSAM) superfamily of enzymes 23, 24, 25 that...

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WebSep 24, 2024 · In humans, mitochondrial iron-sulfur cluster biosynthesis is an essential biochemical process mediated by the assembly complex … WebMar 21, 2024 · ISCU iron-sulfur cluster assembly enzyme Gene ID: 23479, updated on 23-Sep-2024 Gene type: protein coding Also known as: HML; ISU2; NIFU; NIFUN; hnifU; …

WebDuring its late steps, the mitochondrial iron-sulfur cluster (ISC) assembly machinery leads to the formation of [4Fe-4S] clusters. In vivo studies revealed that several proteins are … WebPseudomonas aeruginosa H26023 Pathway: [2Fe-2S] iron-sulfur cluster biosynthesis: Detail Level: If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity. Synonyms: [Fe-S] cluster biosynthesis; [2Fe-2S] cluster biosynthesis . BioCyc ID: PWY-7250 Superclasses: Biosynthesis → Cofactor, Carrier ...

WebIron–sulfur clusters (Fe/S clusters) are essential cofactors required throughout the clades of biology for performing a myriad of unique functions including nitrogen fixation, ribosome assembly, DNA repair, mitochondrial respiration, and metabolite catabolism. WebApr 12, 2024 · On the other hand, as mtACP also participates in iron-sulfur cluster assembly , we evaluated the effect of α-LA supplementation on the downregulated proteins involved in iron-sulfur cluster assembly and aconitase activity, an iron-sulfur dependent enzyme. Our results showed that iron-sulfur cluster metabolism and iron-sulfur group-dependent ...

The assembly of iron-sulfur clusters cluster begins with the production of the equivalent of a sulfur (sulfur atoms per se are not found in nature). The required S atom is obtained from cysteine by the action of so-called cysteine desulfurases. One prominent desulfurase is called Isc. Not only is cysteine the source of S, a cysteine residue in IscS is participates in the abstration. Furthermore, a cysteine residue is the partner protein IscU plays a role is relaying the S atom to ir…

WebDescription Myopathy with deficiency of iron-sulfur cluster assembly enzyme is an inherited disorder that primarily affects muscles used for movement ( skeletal muscles ). This … nutritional values of carbohydratesWebAll of these paths share common themes. This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe–S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron–sulfur cluster scaffold protein (IscU/ISU). nutritional values of chia seedWebMany iron–sulfur enzymes contain the cluster near or at the active site, indicating key roles of these cofactors in catalysis ... Under most conditions, E. coli uses a general ISC … nutritional values of fast food